The regulatory role of SIRPα in synaptic pruning was evident in a model of Alzheimer’s Disease, where the authors observed that the loss of microglial SIRPα increased synaptic loss mediated by microglia engulfment and enhanced cognitive impairment, while, in human tissue, microglial SIRPα expression declines alongside the progression of Alzheimer’s disease [98]. This evidence concerns the gene SIRPA and Alzheimer disease.