Similarly, increased levels of NF-L have been observed in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), SMA type I, Charcot–Marie–Tooth disease, and adult-onset leukoencephalopathy with axonal spheroids and pigmented glia [25,26,27,28,29,30,31]. This evidence concerns the gene NEFL and multiple sclerosis.