It is important to mention a recent study suggesting that a VUS can be associated with an increased risk of cardiac mortality and heart failure hospitalization, especially those VUSs located in definite genes (ACTC1, BAG3, DSP, FLNC, LMNA, MYH7, NEXN, PLN, RBM20, TNNC1, TNNT2, TPM1, TTN, and VCL) [21]. Here, ACTC1 is linked to heart failure.