It is important to mention a recent study suggesting that a VUS can be associated with an increased risk of cardiac mortality and heart failure hospitalization, especially those VUSs located in definite genes (ACTC1, BAG3, DSP, FLNC, LMNA, MYH7, NEXN, PLN, RBM20, TNNC1, TNNT2, TPM1, TTN, and VCL) [21]. This evidence concerns the gene PLN and heart failure.