TNF and Cognitive impairment: Symptoms of cognitive impairment, memory and anosmia, chronic hyperinflammation, described as secondary effects of acute SARS-CoV-2 infection, lead to the release of proinflammatory interleukins (IL-6 and IL-1), tumor necrosis factor-α (TNF-α), and ROS, which can cause long-term damage to the BBB, favoring the entry of SARS-CoV-2 into the brain, in addition to its direct entry through the nasal cavity or bloodstream, which originates the activation of microglia and favors the chain of inflammation and structural damage [13,23].