Studies have elucidated that IL-13Rα2 expression and subsequent IL-13Rα2-mediated signaling pathways contribute to tumor proliferation, invasion, metastasis, and cellular survival across a spectrum of human cancers, including GBM, prostate, lung, ovarian, pancreatic, gastric, and breast carcinomas [14,15,16,17,18,19,20]. The gene discussed is IL13RA2; the disease is breast carcinoma.