The value of LAMP-2-ANCA seropositivity as a biomarker may be greatest among AAV patients who have MPO/PR3-ANCA-negative SVV, but more so in individuals with middle vessel vasculitis (MVV), namely, polyarteritis nodosa (PAN) and large vessel vasculitis (LVV), namely Takayasu’s arteritis (TAK). Here, MPO is linked to polyarteritis nodosa.