In contrast, and despite no association between ANCA titers and hypertension (Figure 3D) [19], we observed significantly elevated LAMP-2-ANCA concentrations in individuals with cardiovascular involvement (mean LAMP-2-ANCA 3475.6 ng/mL) versus those individuals without this manifestation (mean LAMP-2-ANCA 1538.9 ng/mL; p = 0.0003) (Figure 3C). The gene discussed is LAMP2; the disease is hypertensive disorder.