The role of macrophages and their activation of advanced glycation end products, reactive oxygen species, and inducible nitric oxide synthase (iNOS) have been studied in several glomerular diseases such as IgA nephropathy, diabetic nephropathy, and C3 glomerulonephritis [3,4,5,6,7,8,9,26]. The gene discussed is NOS2; the disease is glomerular disorder.