“Negative regulation of blood coagulation,” in which PDGFB and PDGFA are included, was downregulated in patients with IPF (Table 2), whereas “negative regulation of plasminogen activation”, in which SERPINE1 is included, was upregulated by PFD treatment (Table 4) and “negative regulation of blood coagulation” and “negative regulation of plasminogen activation,” in which SERPINE1 and SERPINE2 are included, was upregulated by NTD treatment (Table 6). The gene discussed is SERPINE2; the disease is polyostotic fibrous dysplasia.