Su et al. demonstrated that RAS-responsive element-binding protein 1, a RAS transcriptional effector, is a key partner of TGF-β-activated Smad transcription factors in EMT, suggesting that the RAS oncogene family could play an important role in the regulation of epithelial plasticity and its pathophysiological consequences in lung fibrosis [19]. The gene discussed is RREB1; the disease is pulmonary fibrosis.