PLA2G4A (phospholipase A2 group IVA), RNLS (renalase, an FAD-dependent amine oxidase), and HLA-DOA (major histocompatibility complex class II DO alpha) were downregulated by NTD treatment, although they were not upregulated in patients with IPF compared with HCs. The gene discussed is HLA-DOA; the disease is idiopathic pulmonary fibrosis.