Further, WB results exhibited that curcumin was able to inhibit HIF-1α and PD-L1 expression in the inflammatory environment established by LPS-stimulated CT26 cells (Figure 4I,J), suggesting that curcumin suppressed tumor immune escape by inhibiting the TLR4/HIF-1α/PD-L1 pathway. This evidence concerns the gene TLR4 and neoplasm.