CAT and sickle cell disease: Increased membrane lipid peroxidation is characteristic of several RBC diseases, such as sickle cell disease, thalassemia, unstable hemoglobin disease, etc. In addition, placental ischemia in preeclampsia has been found to reduce the antioxidant activity of glutathione peroxidase and catalase, enzymes, responsible for the degradation of H2O2 in RBCs [74].