NLRP3 and infection: Additionally, the distribution of the haplotypes of NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, and ATG16L1, with a frequency greater than 5% in HC, were similar between COVID-19 patients with mild, moderate, severe, and critical infection, and HC (Table 5 and See Supplementary Table S16—Supplementary Materials).