In a further step, no statistically significant differences in the genotypic and allelic frequencies of each polymorphism studied in NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and MIF were disclosed when COVID-19 patients with mild, moderate, severe, and critical infection were compared to the HCs (see Table 1, Table 2, Table 3 and Table 4 and Supplementary Tables S11–S14—Supplementary Materials). This evidence concerns the gene ATG16L1 and infection.