No statistically significant differences in the haplotypic distribution of NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, and ATG16L1, with a frequency greater than 5% in the HCs, were observed between the COVID-19 patients with mild, moderate, severe, and critical infection (see Table 5 and Supplementary Table S15—Supplementary Materials). This evidence concerns the gene CARD8 and infection.