Patients with mild, moderate, severe, and critical COVID-19 showed similar allelic and genotypic frequencies in the SNPs studied in NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and MIF (see Table 1, Table 2, Table 3 and Table 4 and Supplementary Tables S1–S10—Supplementary Materials). This evidence concerns the gene NLRP3 and COVID-19.