In particular, NLRP3 and NLRP1 inflammasome activation—as well as the components of its signaling, i.e., CASP1, IL-1β, and IL-18, etc.—show a relationship with the inflammatory factors and disease progression in patients with COVID-19 [5,6,7,8,9,15,16,17,18]. This evidence concerns the gene IL1B and COVID-19.