Accordingly, we aimed to elucidate on the role of polymorphisms located in key genes in the formation and signaling of the inflammasome (NLRP3, NLRC4, NLRP1, CARD8, CASP1, IL1B, IL18, NFKB1, ATG16L1, and MIF) as biomarkers of COVID-19 severity, which was achieved via evaluating a large and well-defined cohort of 377 patients with SARS-CoV-2 infection. This evidence concerns the gene NLRC4 and COVID-19.