INS and Insulin resistance: At the same time, Da-Wei Huang and others found that cinnamic acid can promote tyrosine phosphorylation of insulin receptors, up-regulate the expression of insulin signal-related proteins, including insulin receptor, phosphatidylinositol 3 kinase (PI3K), glycogen synthase (GS) and glucose transporter 2 (GLUT2), and increase glucose uptake, thus reducing insulin resistance in cells [189].