We performed multivariate regression analyses to evaluate the associations between AD biomarkers (CSF Aβ42 and p-tau) and CSF levels of eNOS and nNOS, accounting for other possible influencing factors such as age, sex (M = 0, F = 1), Qalb and the degree of cognitive impairment (MMSE). This evidence concerns the gene NOS1 and Cognitive impairment.