We also analyzed the vascular angioarchitecture of the primary tumor and, similarly to the HCC model in Dhx15+/− mouse, we observed alterations in the vasculature in terms of a significantly reduced vascular perimeter and lumen of blood vessels detected by endomucin immunostaining and a significant reduction in lymphatic vessels detected by Lyve-1 immunostaining in the AUMsilence ASO Dhx15 group compared to the AUMscramble ASO scramble group (Figure 6B). This evidence concerns the gene EMCN and neoplasm.