Loss-of-function (LOF) mutations in the ANGPTL3 gene determine familial combined hypolipidemia (FHBL2), a disorder characterized by very low levels of apolipoprotein B (apoB), apolipoprotein A1 (apoA-1) and their associated lipoproteins VLDL, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), compared to non-carriers [7]. This evidence concerns the gene APOA1 and familial hypobetalipoproteinemia 2.