ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Fetuin-A stimulates the sensitization of TLR-4 in adipocytes and macrophages to promote the pro-inflammatory scenario in conjunction with FFAs, directing IR, the suppression of adiponectin synthesis by adipocytes, and the induction of pancreatic β-cell toxicity; thus, its levels are shown to be elevated in obesity in correlation with MAFLD [151,168].