Hepatokines are related to the development of MAFLD and NASH through signaling pathways such as adipogenesis, fibrogenesis, pregnane X receptor (PXR)/RXR, farnesoid x receptor (FXR)/retinoic X receptor (RXR), hepatic stellate cell activation, liver X receptor (LXR)/RXR, NF-κB, PPAR, PPARα/retinoic acid receptor alpha, AMP-activated protein kinase (AMPK), and DM2 [174]. The gene discussed is NR1I2; the disease is metabolic dysfunction-associated steatohepatitis.