STAT6 and gastroesophageal reflux disease: Also, a tendency towards higher heartburn incidence in the STAT6 rs324011 G/G genotype compared to G/A + A/A genotypes (50.00% vs. 16.67%, p = 0.091), and in the STAT6 rs12368672 G/G genotype compared to the G/C + C/C genotypes (46.15% and 13.33%, p = 0.096), was observed (Table 3).