Finally, a recent publication has shed some light on the significance of the COL1A2 gene, the fourth gene in the GPI, showing that mRNA expression of COL1A2 (type 1 collagen) was significantly associated with worse prognosis in patients with diffuse glioma in the TCGA and CGGA cohorts (log rank p < 0.001) and although the study was specifically for diffuse low-grade gliomas, the genes involved were selected by an overlap with high-grade gliomas [43]. The gene discussed is COL1A2; the disease is central nervous system cancer.