NFAT5 overexpression in Ishikawa downregulated genes like ankyrin repeat domain 1 (ANKRD1) (log2FC = −0.855) coding, a transcription factor that positively regulates apoptosis [47] and amine oxidase copper containing 3 (AOC3) (log2FC = −0.358), which at low levels is associated with poor prognosis in cancers [48]. The gene discussed is AOC3; the disease is cancer.