The enrichment pathways identified following KEGG analysis that contained the most core targets included lipid and atherosclerosis, the C-type lectin receptor signaling pathway, the IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Chagas disease, the HIF-1 signaling pathway, the TNF signaling pathway, and more (Figure S10B). The gene discussed is TNF; the disease is Chagas disease.