The enrichment pathways identified following KEGG analysis that contained the most core targets included prostate cancer, fluid shear stress and atherosclerosis, prolactin signaling pathway, proteoglycans in cancer, PD-L1 expression and the PD-1 checkpoint pathway in cancer, the relaxin signaling pathway, the IL-17 signaling pathway, and more (Figure S6B). The gene discussed is CD274; the disease is prostate cancer.