Necroptosis is also implicated in PD/DLB by the results that nectrostatin, an inhibitor of necroptosis, partially (nearly 30%) suppressed the MPTP-induced model of PD [77], while the other study suggested the toxicity of necrostatin on cell death in primary fibroblasts from PD patients with and without the G2019S leucine-rich repeat kinase 2 (LRRK2) mutation and in rotenone-treated cells (SH-SY5Y and fibroblasts) [78]. The gene discussed is LRRK2; the disease is Parkinson disease.