PTPN11 and hematologic disorder: The results are summarized in Figure 2, where, among the GVs associated with hematological diseases, we identified: 3 patients with a mutation in exon 3 of PTPN11 gene (transcript NM_001330437: AA substitution p.A72V with a variant transcripts ratio (TR) of 31%; NM_001330437:p.E76K, TR = 48% and NM_001330437:p.A72T, TR = 24%); 1 patient with a mutation in exon 2 of IDH2 (NM_002168:p.R140Q, TR = 36%); and another patient with a mutation in exon 2 of NRAS (NM_002524:p.G12D, TR = 48%).