The most frequent mutations of IDH2, impacting over 95% of patients with IDH2 mutations, predominantly involve the arginine residues at positions R140 and R172 [16], while approximately 90% of IDH1 mutations in AML involve the substitution of arginine for histidine at position 132 (R132H) [17]. This evidence concerns the gene IDH1 and acute myeloid leukemia.