The gene FAM65B is repeatedly shown as differentially methylated in some studies, and the CpG sites from chromosome 6 annotated to gene FAM65B had more variability in acute myeloid leukemia cases than in controls, suggesting its importance for lymphatic–hematopoietic cancers [28,29]. The gene discussed is RIPOR2; the disease is hematopoietic and lymphoid cell neoplasm.