Existing research in the field of lung cancer has indicated that the high expression of specific genes, including COL1A2, POSTN, DSG2, CDKN2A, COL1A1, SLC2A1, SERPINB5, and SPP1, can facilitate the diagnosis of NSCLC and correlate with poorer patient outcomes [46]. The gene discussed is COL1A1; the disease is lung cancer.