Moreover, a panel consisting of eight genes associated with the extracellular matrix (FERMT1, CTSV, CPS1, ENTPD2, SERPINB5, ITGA8, ADAMTS8, and LYPD3) has been constructed, which has been linked to shorter survival, worse immunological outcomes, and higher tumor purity in lung adenocarcinoma patients [47]. This evidence concerns the gene LYPD3 and lung adenocarcinoma.