The study of Baião et al. [19] showed that long-term exercise intervention significantly reduced the levels of C-reactive protein (CRP) (SMD: −0.23; 95% CI: −0.39 to −0.06) and pro-inflammatory cytokines such as IL-6 (SMD: −0.35; 95% CI: −0.57, −0.14) and TNF-α (SMD: −0.63, 95% CI: −1.01, −0.25) in patients with CKD, and increased the level of IL-10 (SMD: 0.66, 95% CI: 0.09, 1.23), proving that exercise intervention can alleviate kidney damage by relieving inflammation. The gene discussed is CRP; the disease is chronic kidney disease.