LGALS3 and in situ carcinoma: Immunofluorescent staining for p-AMPK revealed a significantly higher number of cells expressing p-AMPK in the kidneys of the CIS-treated Gal-3 KO mice (Figure 8D,E) than in the CIS-treated Gal-3 wild-type mice (p < 0.001) (Figure 8B,E).