The CIS-treated Gal-3 KO group showed ATN involving 69.66% ± 3.35% of renal parenchyma (Figure 2I) with the loss of brush borders, swelling of tubular cells, intratubular falling cells, intratubular secretions and mitosis (Figure 2G,H). This evidence concerns the gene LGALS3 and in situ carcinoma.