Therefore, it is conceivable that the suppression of AMPK activity induced by the enhanced IL-1β, and TNFα in sensory neurons in lupus mice may result in ERK activation, subsequently leading to the phosphorylation of sodium channel Nav1.7, and thereby lowering the action potential activation threshold in nociceptive sensory neurons [28] (Figure 2). This evidence concerns the gene TNF and systemic lupus erythematosus.