Angiotensin II (Ang II), endothelin-1 (ET-1), and insulin-like growth factor-1 (IGF-1) are some of the known neurohumoral factors that can induce cardiac hypertrophy via receptor tyrosine kinases or G-protein-coupled receptors such as Gαq [20,30]. The gene discussed is EDN1; the disease is cardiac hypertrophy.