The A1CF RRM deletion mutants, particularly A1CF ∆RRM1, nearly rescued the reduction in p65(Ser536) phosphorylation and IFN-β expression (Figure 6B) and abolished A1CF-promoted renal cancer cell proliferation as measured by the EdU (Figure S3A,B) and MTT (Figure S4C) assays. The gene discussed is RELA; the disease is renal carcinoma.