ZHX2 was reported as an oncoprotein that promotes p65 nucleus translocation without affecting p65 phosphorylation in ccRCC, and the depletion of p65 decreases cell proliferation and anchorage-independent growth [59]; however, the role of p65 phosphorylation in RCC remains unclear. The gene discussed is ZHX2; the disease is nonpapillary renal cell carcinoma.