Patients with certain TRPV4-mediated neuropathies may develop skeletal dysplasias [69,70], which are autosomal dominant disorders that include autosomal dominant brachyolmia type 3, spondylo-epimetaphyseal dysplasia maroteaux pseudo-Morquio type 2, spondylometaphyseal dysplasia Kozlowski type, parastremmatic dysplasia, and metatropic dysplasia. Here, TRPV4 is linked to skeletal dysplasia.