In addition, in different tumor cells, β-caryophyllene oxide (68) can simultaneously target PI3K/AKT/mTOR/S6K1 and MAPK signaling pathways, inhibit the proliferation of related tumor cells and induce the apoptosis of tumor cells by activating caspase-3 and releasing cytochrome c. The gene discussed is RPS6KB1; the disease is neoplasm.