It is well known that phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase 1 (S6K1) and mitogen-activated protein kinase (MAPK) signaling cascades play an important role in many physiological processes of tumor cells, including cell proliferation, survival, angiogenesis, and metastasis of tumor cells. This evidence concerns the gene RPS6KB1 and neoplasm.