PIK3CD and colorectal neoplasm: In addition, total flavonoids from T. hemsleyanum, which mainly contain K3OR, rutinum, isoquercitrin, L-epicatechin, quercetin, astragalin, kaempferol 3-sambubioside, and catechin could inhibit the PI3K/AKT/mTOR pathway and thus delay colorectal tumor growth [31].