CD274 and lip and oral cavity carcinoma: Hesperidin (24) exerts anti-cancer effects on OCC by inactivating transcriptional actvator 1 (STAT1) and STAT3 signalling molecules and inhibiting programmed cell death 1 ligand 1 (PD-L1) expression [59].Velmurugan et al. [60] demonstrated for the first time that luteosin-7-O-glucoside (25) inhibits the invasion and migration of OCC by regulating matrix metalloproteinase-2 (MMP-2) expression and the extracellular signal-regulated kinase pathway and significantly reduces the metastasis of oral cancer by alleviating the P38-induced increase in MMP-2 expression.