Silibinin also demonstrates a defense activity against sunlight-induced skin cancer by downregulating angiogenic response, involving gene-regulating proteins of NF-κB, COX-2, STAT3, HIF-1α, iNOS, and their potential upstream regulators, p-STAT3 and phospho-p65 in skin cancer triggered by ultraviolet [85]. This evidence concerns the gene HIF1A and skin neoplasm.