HIF1A and neoplasm: Isolated from Sorbariasorbifolia, TTF1, also known as 5,2′,4′-Trihydroxy-6,7,5′-trimethoxyflavone, has showcased its capacity to inhibit tumor angiogenesis elicited by HepG-2 cells via reducing the VEGF, KDR, bFGF, COX-2, and HIF-1α levels of RNA and protein in key factors regulating angiogenesis [27].