It downregulates the levels of HIF-1α, GLUT-1, and VEGF in pancreatic carcinoma [58] and inhibits the level of MMP-2, MMP-9, uPA, and VEGF in TRAMP mouse by downregulating IGF-I/IGFBP-3 signaling [59]. Here, IGFBP3 is linked to exocrine pancreatic carcinoma.