The reported mechanisms include the inhibition of the PI3K-AKT signaling pathway [37], the Akt/WEE1/CDK1 signaling pathway [38], the EGFR signaling pathway [39], and the ATF4-JAK signaling pathway [40], etc. But the antitumor mechanisms of TIIA have not been illuminated, or whether TIIA has the ability to regulate ERS and ferroptosis, thereby promoting cell apoptosis and inhibiting tumor growth. The gene discussed is ATF4; the disease is neoplasm.