EGFR and neoplasm: The reported mechanisms include the inhibition of the PI3K-AKT signaling pathway [37], the Akt/WEE1/CDK1 signaling pathway [38], the EGFR signaling pathway [39], and the ATF4-JAK signaling pathway [40], etc. But the antitumor mechanisms of TIIA have not been illuminated, or whether TIIA has the ability to regulate ERS and ferroptosis, thereby promoting cell apoptosis and inhibiting tumor growth.