It is known that IL-6 induces excess production of VEGF and EGF, leading to enhanced angiogenesis and increased vascular permeability which are pathological features of inflammation lesions seen in synovial tissues of rheumatoid arthritis (RA) or edema of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome [53]. This evidence concerns the gene IL6 and rheumatoid arthritis.