PLOD2 and neoplasm: For example, tumor stroma contains higher levels of hydroxylysine aldehyde-derived collagen cross-links and lower levels of lysine aldehyde-derived cross-links compared to normal lung tissues due to the higher expression of LH2, which indicates that LH2 enhances the collagen metastatic properties of tumor cells and functions by controlling the relative abundance of hydroxylysine aldehyde-derived collagen cross-links in the tumor stroma [245].