ATP Binding Cassette Subfamily A Member 1 (ABCA1) and lipase C (LIPC) are related to the presence of intermediate and large drusen, while complement factor H, C3, C2, and age-related maculopathy susceptibility 2/HTRA serine peptidase 1 (ARMS2/HTRA1) are associated with large drusen and advanced AMD [36,54,55,56,57,58]. Here, C3 is linked to age-related macular degeneration.