Alveolar edema, with intra-alveolar and/or pleural hemorrhage, and alveolar septa ICAM-1 and AQP-1 positive expression, along with subarachnoid hemorrhage, intraparenchymal and perivascular hemorrhages, diffuse perineuronal and perivascular edema, gliosis, mononuclear cell infiltration, focal neuronal ischemia, lacunar infarction, S100β immunopositive expression of glial cells and moderate neurons’ Hsp70 immunopositivity were the most significant microscopic lesions registered in hypothermia-related deaths. Here, S100B is linked to ischemia.