Regarding the interpretation of the results, the comparison with normal thermal status could not be achieved, considering the high variability of circumstances of death and related pathologies, with possible brain S100β and Hsp70 expression associated with agonal cerebral edema and neuronal ischemia and lung ICAM-1 and AQP1 expression associated with pulmonary edema related to alveolar and endothelial lesions. The gene discussed is S100B; the disease is brain edema.