With Lumipulse HBcAb-II® (Fujirebio, Tokyo, Japan), which detects both the IgM and IgG types, the differentiation of acute and chronic hepatitis used to be considered difficult, but newer Lumipulse HBcAb-N® is reported to detect IgG antibody alone and to be unaffected by the IgM antibody [14]. The gene discussed is CD40LG; the disease is chronic hepatitis.