KRT88P and hepatocellular carcinoma: On the other hand, in 2016, a meta-analysis of 26 original studies reported an increased risk of HCC with an HR of 1.36 for HBs antibody-positive/HBc antibody-positive cases and an HR of 2.15 for HBs antibody-negative/HBc antibody-positive cases compared to HBs antibody-negative/HBc antibody-negative individuals [44].