- Functional: A sign of early chronic pancreatitis is the visualization of side branches at body-tail after secretin injection; a hindered pancreatic juice outflow is related to a prolonged and abnormal dilatation of the MPD (>3 mm 10 min after secretin injection); the parenchymogram (parenchymal enhancement) is a sign of recurrent acute pancreatitis (Figure 22); a decrease in pancreatic exocrine reserve is explained by a reduced duodenal filling [47]. The gene discussed is SCT; the disease is chronic pancreatitis.