An in vitro investigation of the effects of flavonol and PACs-enriched fractions of cranberry on PCa cells showed apoptotic effects against the DU145 cell line at different concentrations (25, 50, and 100 μg/mL) by activating the expression of genes responsible for cytochrome C release from the mitochondria, including caspase-8/9, prostate apoptosis response-4 gene (Par-4), truncated Bid (tBid), and Bcl-2-associated X protein (Bax) [51]. Here, PAWR is linked to posterior cortical atrophy.