KRT8 and neoplasm: To identify the extent of transcriptome remodeling in HCs from tumors (THC), we extracted the tumor fraction and compared the gene expression profile of THC with tumor epithelial cells (EPCAM+ and KRT8+) (Figure 1H and Supplementary Table S1) and THCs with tumor-associated macrophage/monocyte cells (CD14+ and CD163+) (Figure 1I and Supplementary Table S2).