In fact, increased baseline IL-17 concentrations were frequently associated with ICI-mediated colitis and severe diarrhea in melanoma patients treated with ipilimumab; increased IL-6 and IL-10 concentrations were found in patients presenting skin irAEs; increased concentrations of IL-1β, IL-2, and GM-CSF have been associated with ICI-mediated thyroid dysfunctions [84,85,86]. The gene discussed is IL1B; the disease is melanoma.