Interestingly, a study investigating large panels of circulating cytokines as irAEs’ prediction factors demonstrated that eleven cytokines (G-CSF, GM-CSF, fractalkine, FGF-2, IFN-α2, IL-12p70, IL-1α, IL-1β, IL-1RA, IL-2, and IL-13) were strongly associated with an increased risk of developing irAEs in melanoma patients treated with ICIs [84,87]. This evidence concerns the gene CSF2 and melanoma.