The GSEA analysis of TCGA PRAD data highlighted the SETD2 gene as potentially playing a pivotal role in several cellular pathways, notably impacting the AMPK, cAMP, and PI3K-Akt signaling pathways, contributing to tumor progression, and fostering prostate cancer cell proliferation, invasion, and metastasis [30]. Here, SETD2 is linked to Familial prostate cancer.