Specifically, high-risk SETD2 association with ERG positive cases revealed poorer OS and CSS survival curves, with 95% CI and HR = 3.30 (1.96–5.58, p < 0.0001) and HR = 7.64 (3.59–16.25, p < 0.0001) for OS and CSS for PCa, respectively. Here, SETD2 is linked to posterior cortical atrophy.