AKT1 and neoplasm: Furthermore, we obtained the positive and negative correlated gene lists and the top 50 genes presented in Figure 4D. The gene set enrichment analysis (GSEA) revealed potential enrichments associated with SETD2 gene expression, including the AMPK signaling pathway, the cAMP signaling pathway, and the PI3K-Akt signaling pathway, which are potentially associated with tumor progression, chemoresistance, and a poor prognosis (Figure 5).