Increased levels of TNF-α have been reported in several immunological diseases, and its prominent role was observed in various human diseases such as different types of arthritis, inflammatory bowel disease, bacterial and viral infections, insulin resistance and type II diabetes, Alzheimer’s, cancer, etc. Essentially, it is the pro-inflammatory role of TNF-α that is observed in many of these immune-associated diseases and disorders. The gene discussed is TNF; the disease is arthritic joint disease.