CD8A and neoplasm: Some components, such as myeloid cells and desmoplastic components in the TME, have been reported to impact the distribution of CD8+ T cells, while the role of local communication patterns around CD8+ T cells has yet to be defined [17,18,19,22,34].The proximity of CD8+ T cells to tumor cells has been well known to facilitate the recognition of tumor-associated antigens and subsequent tumor eradication [1,2,3,4,5].To assess the proximity of CD8+ T cells to tumor cells, we examined the distance from CD8+ T cells to their nearest tumor cells.