For instance, transcriptomics profiles and protein expressions were assessed in samples from normal cervixes, HPV types 16/18-positive, low-grade CIN (LGCIN), high-grade CIN (HGCIN), and squamous cell carcinoma (SCC), demonstrating upregulations of CD74 and HLA-DRA from normal cervix to CIN with the highest in SCC [76]. This evidence concerns the gene CD74 and cervical squamous intraepithelial neoplasia.