Regarding acute toxicities, no significant difference was observed between the carriers of a rare monoallelic PV or predicted PV ATM carriers and carriers of the minor allele A of SNP rs1801516 as compared to noncarriers (dermatitis: p = 0.65/ dysphagia: p = 1/ lymphoedema: p = 1) (Figure S2). This evidence concerns the gene ATM and lymphedema.