SPINK1 and neoplasm: The oncogene-enriched type mainly involves upregulated genes related to tumor cell proliferation and invasion, including Claudin3 (CLDN3), Claudin4, serine peptidase inhibitor Kazal type 1 (SPINK1), epithelial splicing regulatory protein 1 (ESRP1), and epithelial cell adhesion molecule (EpCAM) [54,55].