On the other hand, the recommendations of the European Society for Medical Oncology (ESMO) differ slightly from those of the IKWG with regard to low proliferation; in the ESMO recommendations, all tumours with Ki-67 ≤ 10% are considered to be clearly low proliferative, and those with Ki-67 ≥30% highly proliferative [31]. This evidence concerns the gene MKI67 and neoplasm.